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Science immunology

Ritvo PG, Churlaud G, Quiniou V, Florez L, Brimaud F, Fourcade G, Mariotti-Ferrandiz E, Klatzmann D.
PMID: 28887367
Sci Immunol. 2017 Sep 08;2(15). doi: 10.1126/sciimmunol.aan0368.

Follicular regulatory T (T

What to expect when you're expecting.

Science immunology

Chattopadhyay PK.
PMID: 28864495
Sci Immunol. 2017 Sep 01;2(15). doi: 10.1126/sciimmunol.aao3543.

Applying systems immunology to study human pregnancy.

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Science immunology

Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MS, Fogg LG, Nair AS, Liligeto U, Stubbington MJ, Ly LH, Bagger FO, Zwiessele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA.
PMID: 28345074
Sci Immunol. 2017 Mar 03;2(9). doi: 10.1126/sciimmunol.aal2192.

Differentiation of naïve CD4

The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Science immunology

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.
PMID: 28670633
Sci Immunol. 2016 Sep 02;1(3). doi: 10.1126/sciimmunol.aaf8864.

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. In Crohn's disease, this manifests itself as recurrent gastrointestinal strictures for which there is no effective...

Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8.

Science immunology

Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts IM, Coffey DG, Warren E, Robbins H, Greenberg PD, Yee C.
PMID: 28367538
Sci Immunol. 2017 Feb;2(8). doi: 10.1126/sciimmunol.aal2568. Epub 2017 Feb 24.

Adoptively transferred tumor-specific cells can mediate tumor regression in cancers refractory to conventional therapy. Autologous polyclonal tumor-specific cytotoxic T cells (CTL) generated from peripheral blood and infused into patients with metastatic melanoma show enhanced persistence, compared to equivalent numbers...

Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome.

Science immunology

Zuber J, Shonts B, Lau SP, Obradovic A, Fu J, Yang S, Lambert M, Coley S, Weiner J, Thome J, DeWolf S, Farber DL, Shen Y, Caillat-Zucman S, Bhagat G, Griesemer A, Martinez M, Kato T, Sykes M.
PMID: 28239678
Sci Immunol. 2016 Oct;1(4). doi: 10.1126/sciimmunol.aah3732. Epub 2016 Oct 07.

A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft T cells over time has not been investigated in detail in animals or humans. Here, we use polychromatic...

Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation.

Science immunology

Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D.
PMID: 28733470
Sci Immunol. 2017 Jul 21;2(13). doi: 10.1126/sciimmunol.aal1329.

Dendritic cell (DC) activation and antigen presentation are critical for efficient priming of T cell responses. Here, we study how lentiviral vectors (LVs) deliver antigen and activate DCs to generate T cell immunization in vivo. We report that antigenic...

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

Science immunology

Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P.
PMID: 28763793
Sci Immunol. 2017 May 12;2(11). doi: 10.1126/sciimmunol.aam7341.

The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4

Commensal bacteria (ab)use CD8.

Science immunology

Ma C, Greten TF.
PMID: 28738021
Sci Immunol. 2017 Apr 21;2(10). doi: 10.1126/sciimmunol.aan1473.

Type I interferon-dependent expansion of intrahepatic CD8

In SLE genetics, white does not equal black, 1+1 does not equal 2.

Science immunology

Davis LS.
PMID: 28778906
Sci Immunol. 2017 Aug 04;2(14). doi: 10.1126/sciimmunol.aao3114.

A transancestral SLE study examining the relationship between genetic load and disease risk.

Science immunology

Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin JW, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C.
PMID: 28783657
Sci Immunol. 2017 Jun 02;2(12). doi: 10.1126/sciimmunol.aam8093.

Although malaria is a life-threatening disease with severe complications, most people develop partial immunity and suffer from mild symptoms. However, incomplete recovery from infection causes chronic illness, and little is known of the potential outcomes of this chronicity. We...

PD-1 blockade: It's what's for dinner.

Science immunology

Griffin GK.
PMID: 28783659
Sci Immunol. 2017 Jun 02;2(12). doi: 10.1126/sciimmunol.aan8155.

Tumor-associated macrophages limit the efficacy of programmed cell death 1 (PD-1) blockade through an FcγR-dependent clearance mechanism.

Showing 1 to 12 of 440 entries